The Ugo Basile Learned-Helplessness Apparatus is widely used for assessing depression in rats and mice. When rodents are exposed to inescapable and unpredictable stress, such as forced swim or inescapable footshock, they often develop deficits in memory and learning tasks (e.g. Active Avoidance), and often show analgesic reactions (S.I.A. Stress-Induced Analgesia).
The Ugo Basile Learned Helplessness system includes a dark isolation cube, in which the subject is placed, and a controller. The chamber is outfitted with an electrified grid floor, and connected to the controller which consists of a shock generator and a timer. The system also includes a user-friendly reporting software, to collect, visualize and export into spreadsheets the delivered shocks. Shocks can be randomized on the basis of duration and interval between shock events. More complex trains of shocks can also be programmed.
Mouse or Rat cages are available. This system is expandable, for stimulation of up to 4 animals simultaneously.
57500 Ugo Basile Learned Helplessness for Rat
57501 Ugo Basile Learned Helplessness for Mouse
57500-010 Software Activation Code for Learned Helplessness